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Efficacy
- Glucanol ™ Increases Microbial Killing. In clinical studies, Glucanol’s™ highly purified and biologically active 1-3,1-6 beta glucan significantly increased phagocytic capacity, the ability of the innate immune cells to eat and destroy foreign intruders. After 10 days of treatment, Glucanol™ had increased the percentage of immune cells able to phagocytose one particle from 63.8% to 83.2% (P< .05). The number of highly phagocytic cells increased from 37.3% to more than 50% (P< .05).
- Glucanol™ Increases Immune Cell Activity. A placebo-controlled, double-blinded clinical study conducted with 62 subjects to assess the impact of the ingredients in Glucanol™ on immune biomarkers for subjects exposed to rhinovirus (common cold) was conducted. Generally, the immune system responds to viral infections with an increase in Natural Killer (NK) cells and cytotoxic T cells as primary defense mechanisms. Participants receiving Glucanol’s™ ingredient had more NK cells and cytotoxic T Cells (12.5%) as a percent of all lymphocytes than participants in the control group (9.8%).
- Glucanol™ Enhances Immune Cell Migration to Site of Challenge. Glucanol’s™ active form enhances the ability of certain human immune cells to migrate to the site of a bacterial infection. Neutrophils, the most abundant type of innate immune cell in the body, are attracted to the site of an infection by blood proteins called chemo-attractants and are among the first cells of the body to respond to a challenge due to infection or injury. Priming neutrophils with Glucanol’s™ pharmaceutical grade 1-3,1-6 beta glucan increases their ability to sense complement fragments emanating from the site of an infection. As a result, a more rapid immune response to infection results in faster microbial clearance and healing.
Safety
Studies demonstrate Glucanol™ safely enhances and supports healthy immune system function.
- Animal tox studies with doses ranging from 0 to 1,000 times recommended daily dose.
- Human studies with doses up to 60 times recommended daily dose.
- No increase in tested cytokines or other adverse effects.
- Glucanol™ increased ability of human immune cells to kill foreign challenges.
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